PGE2 regulates ferroptosis and osteogenesis of MC3T3-E1 cells via NOS2.

Sci Rep · 2026 · PMC12987987 · PMID 41796243

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

While the expression changes in ferroptosis-related genes (GPX4, FTH1, ACSL4) and osteogenic markers (RUNX2, OPN) did not reach statistical significance at the mRNA or protein level, NOS2 overexpression significantly elevated ROS and MDA production and potently suppressed ALP activity and mineralization.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.