Barely Significant
← all excerpts

A beneficial effect of a novel DKK1 monoclonal antibody and its sequential alendronate on bone and muscle properties of orchiectomized mice.

J Orthop Translat · 2026 · PMC12988541 · PMID 41836573

Europe PMCDOI
3
hedged sentences
0.0500
closest p · 1.0× alpha
0.0500
boldest claim

The sentences

a decreasing trendP < 0.05actually significant
The Sost expression in alendronate group showed a decreasing trend, which were significantly lower than that in Dkk1-mAb group ( P < 0.05) ( Fig. 2 F). 3.4.

also in 29,876 other papers

an increasing trendno p-value reported
The expression of Wnt-related gene Ctnnb1 in muscle shows an increasing trend in Dkk1-mAb and sequential treatment groups, with an increasing expression of its direct transcriptional target, Axin2 in Dkk1-mAb group.

also in 38,133 other papers

did not reach statistical significanceno p-value reported
The Sost mRNA level in bone tissue of Dkk1-mAb group was numerically higher than that in ORX and Sham groups, although it did not reach statistical significance.

also in 75,868 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.