Cytokine mRNA-based therapy alleviates dendritic cell and T cell paucity to eliminate aggressive pancreatic cancer in preclinical mouse models.

Quantitative analysis of CD11c+ DCs and CD8+ T cells indicated a significantly positive correlation between them (P = 9.92 × 10 −9 ; Supplementary Figure S1A–C ), and clarified that the CD11c-low group exhibited worse RFS (P < 0.001) and OS (P < 0.001), while the CD8-low group only showed a trend towards unfavourable RFS and OS ( Fig. 1 K and L).

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