Pitolisant Improves Depressive Symptoms in CPAP-Treated Patients with Obstructive Sleep Apnea and Severe Residual Sleepiness: First 12-Month Clinical Experience.

CNS Drugs · 2026 · PMC12989008 · PMID 41400754

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did not reach statistical significanceno p-value reported

A reduction in sleepiness occurred early in most patients, with a mean drop of 6 points in the ESS after 3 months, although this change did not reach statistical significance.

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