Increased expression of CD36 and CD163 in clear cell renal cell carcinoma suggests an association between lipid transport and an "M2-like" macrophage phenotype.

CD163 on macrophages positively correlated with CD36 on CD45-negative cells from ccRCC tumors, while CD8 T cells showed a trend to lower numbers in tumors with high CD36 expression on CD45-negative cells.

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While the CD36 levels did not correlate with CD68 expression, the correlation of CD163 and CD36 was highly significant, suggesting a favoring of pro-tumorigenic macrophage subpopulations in ccRCC tumors with increased CD36 levels ( Figure 3A ).

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