Global, regional, and national burdens of liver disease due to hepatitis B in women of childbearing age, 1990 to 2021: an analysis of the Global Burden of Disease Study.

47 , 48 However, this study also found an unfavorable trend in the mortality of liver disease due to hepatitis B in women of childbearing age in Australasia, Eastern Europe, and High-income North America between 1990 and 2021.

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At the regional level, an increasing trend in the mortality of liver disease due to hepatitis B in women of childbearing age between 1990 and 2021 was observed in Australasia (EAPC=0.46; 95% CI: 0.23, 0.68), Eastern Europe (EAPC=3.39; 95% CI: 2.34, 4.45), and High-income North America (EAPC=0.77; 95% CI: 0.57, 0.97).

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The incidence rates of liver disease due to hepatitis B in women of childbearing age were deemed to be in a decreasing trend in 201 countries or territories between 1990 and 2021, with the largest decrease in Brunei Darussalam (EAPC=–4.36; 95% CI: –4.72, –4.00), followed by Poland (EAPC=–3.81; 95% CI: –3.98, –3.64) ( Figure 4, C and eTable 5 ).

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