ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition.

Mol Metab · 2026 · PMC12990342 · PMID 41833222

Europe PMC DOI

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0.0610

closest p · 1.2× alpha

0.0610

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The sentences

a trend toward significanceP = 0.061so close (0.05 < p ≤ 0.1)

Two-way ANOVA showed a trend toward significance for overall treatment effect ( F (3, 44) = 2.644, P = 0.061) and a dose-dependent reduction in food intake was evident at Weeks 2 and 6. 2.2 DA significantly modulates key metabolic biomarkers in mice on HFD in a dose-dependent manner To assess the metabolic effects of DA, five fasting circulating biomarkers, glucose, insulin, LDL, TG, and TC, were measured at baseline and at study termination.

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showed a trendP = 0.061so close (0.05 < p ≤ 0.1)

Two-way ANOVA showed a trend toward significance for overall treatment effect ( F (3, 44) = 2.644, P = 0.061) and a dose-dependent reduction in food intake was evident at Weeks 2 and 6. 2.2 DA significantly modulates key metabolic biomarkers in mice on HFD in a dose-dependent manner To assess the metabolic effects of DA, five fasting circulating biomarkers, glucose, insulin, LDL, TG, and TC, were measured at baseline and at study termination.

also in 33,237 other papers

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