Mast Cells Inhibit Stem Cell-driven Epithelial Repair in Inflammatory Bowel Disease via Suppressing Wnt/lrp6/β-Catenin Signaling Pathway.

At the mRNA level, although the difference of Lgr5 did not reach statistical significance ( Figure 5 J ), WB analysis revealed that Lgr5 protein expression was significantly reduced in BN rats relative to Ws/Ws rats, and Wnt pathway analysis demonstrated a more pronounced suppression of Lrp6 and total and active β-catenin in BN rats compared with Ws/Ws rats ( Figure 5 K–O ).

also in 111,027 other papers