Integrated single-cell and spatial transcriptomics uncover SPP1⁺ and HLA-DRB5⁺ macrophages as key modulators of the immune microenvironment in colorectal cancer liver metastasis.

J Transl Med · 2026 · PMC12990636 · PMID 41715121

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a clear trendno p-value reported

Notably, FUCA1 exhibited a clear trend in which lower expression levels (blue) were predominantly associated with positive SHAP values, indicating increased predicted risk, whereas higher expression levels (red) corresponded to negative SHAP values, reflecting reduced predicted risk.

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