Revisiting Light's criteria: a validated blood-free triple combination matches diagnostic accuracy in over 7000 patients.

ERJ Open Res · 2026 · PMC12991015 · PMID 41846683

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0.0850

closest p · 1.7× alpha

0.0850

boldest claim

The sentences

did not reach statistical significancep=0.085so close (0.05 < p ≤ 0.1)

The double combination (pleural fluid LDH and cholesterol) demonstrated significantly higher AUCs than both Light's criteria and the triple combination in the derivation cohort (p=0.0114 and p<0.001, respectively); however, the difference versus Light's criteria did not reach statistical significance in the validation cohort (p=0.085).

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