Preliminary lipidomics and transcriptomics reveals stage-specific dynamic metabolic patterns from menopause transition to postmenopause.

Front Endocrinol (Lausanne) · 2026 · PMC12991988 · PMID 41852473

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.5000

boldest claim

The sentences

a decreasing trendp < 0.05actually significant

For example, GM1 significantly increased from premenopause to transition group (p < 0.05), while SiE showed a decreasing trend from transition to postmenopause group (p < 0.05) ( Table 3 ).

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did not reach statistical significancep > 0.5not close (p > 0.1)

However, the comparisons between postmenopause and the other groups, while trending similarly, did not reach statistical significance (p > 0.5).

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a positive trendno p-value reported

E2 demonstrated a positive trend of correlation with the four marker genes—CMPK2, MX1, RSAD2, and IFI6—suggesting potential regulatory relationships.

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