Adaptor-mediated recruitment of three dyneins to dynactin enhances force generation.

Moreover, the inclusion of Lis1, which prevents dynein’s autoinhibited state 19 , 48 , 49 , 54 , 57 , showed a trend towards reducing the occurrence of stalling at 2.5 pN (Fig. 2c ; P = 0.078 versus DDB) and significantly increased the fraction of active DDB complexes (Fig. 2d ; P = 0.029 versus DDB).

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