Comparative effectiveness of combination therapy with SGLT-2 inhibitors and GLP-1 RAs compared with SGLT-2 inhibitors in individuals with type 2 diabetes: A prevalent new-user cohort study.

Diabetes Obes Metab · 2026 · PMC12992157 · PMID 41725345

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7 Interestingly, the more distal outcome, renal failure, showed a trend toward a lower hazard (HR 0.91, 95% CI 0.70–1.17), although both confidence intervals were wide and included the null. 4.1 Potential mechanisms The observed benefits likely stem from the complementary mechanisms of both drug classes.

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