CD79A/CD40 intracellular domain uses a 4-1BB-like metabolic pathway driven by cholesterol biosynthesis.

J Immunother Cancer · 2026 · PMC12993329 · PMID 41813235

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did not reach statistical significanceno p-value reported

Consistently, flow cytometric analysis revealed a similar trend of increased LDL receptor expression on the cell surface of CD19.BBz and CD19.CD79a.40z CAR-T cells relative to CD19.CD28z CAR-T cells, though the differences did not reach statistical significance ( figure 7I ).

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