IGSF11-VISTA is a critical and targetable immune checkpoint axis in diffuse midline glioma.

Cancer Cell · 2026 · PMC12994606 · PMID 41576930

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These tumors also showed a trend toward increased microglia at the tumor site and a significantly higher fraction of Vista-expressing microglia ( Figures 7 C and 7D), suggesting that tumor-derived Igsf11 induces the expression of its receptor on microglia in a feedforward loop.

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