TAS2R38 taster variants-linked MGAM expression in Alzheimer's disease: a novel target for precision drug repurposing.

Front Aging Neurosci · 2026 · PMC12996105 · PMID 41858791

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hedged sentences

0.0010

closest p · 0.0× alpha

0.0590

boldest claim

The sentences

highly significantP < 0.001actually significant

TAS2R38 supertasters are associated with lower risk of AD with the advancement of age From LME modeling of the longitudinal change in cognitive assessments and biomarkers in ADNI ( n = 2,168), highly significant interactions ( P < 0.001) were found between age and the alternative allele counts of each of the SNPs.

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a borderline significant trendP = 0.059so close (0.05 < p ≤ 0.1)

In the Kaplan-Meier plot comparing the groups with 1:1 matching, a borderline significant trend ( P = 0.059) can be seen, with the non-users having an earlier dementia diagnosis rate or a higher AD susceptibility than the drug user group ( Figure 4A ).

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