Endothelial C-type natriuretic peptide/guanylyl cyclase-B signaling prevents pulmonary arterial hypertension.

Nat Commun · 2026 · PMC12996325 · PMID 41844596

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did not reach statistical significanceno p-value reported

Adding CNP-53 to macitentan or sotatercept also further reduced RV/(LV + IVS) ratios numerically as compared to monotherapy, but the difference did not reach statistical significance due to the already significant improvement with monotherapy in this model.

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