Validation of a novel cognitive-functional outcome measure optimized for early Alzheimer's Disease: Evidence from the VIVA-MIND trial.

J Prev Alzheimers Dis · 2026 · PMC12996941 · PMID 41830756

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practically significantno p-value reported

Conclusions Practically significant differences in the efficiency of clinical trials in early AD may be realized by the choice of clinical outcome measure and weighting scheme.

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did not reach statistical significanceno p-value reported

Similarly, APOE genotype and education effects on rate of decline also did not reach statistical significance in this sample from the VIVA-MIND trial data.

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