ALOX15-Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gα<sub>q</sub>-PLC-PKC Pathway.

Inhibition of Gα q signaling with YM‐34825 significantly attenuated the suppressive effects of both oxylipins on LPS‐induced TNF‐α and IL‐6 production, although the effect on 12‐HETE‐mediated IL‐6 suppression did not reach statistical significance (Figure 7A–D ).

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