Epigenetic Modulation of the ACE System Underlies the Slow Aerobic Muscle Phenotype and Metabolic Exercise Response.

FASEB J · 2026 · PMC12997149 · PMID 41847930

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0.0670

closest p · 1.3× alpha

0.0670

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The sentences

showed a trendp = 0.067so close (0.05 < p ≤ 0.1)

Consistently, ACE promoter methylation in vastus lateralis muscle was associated with habitual endurance exercise ( p < 0.001, η 2 = 0.059), being 0.220 points higher in the endurance exercising subjects, and showed a trend towards an interaction with the ACE I/D genotype ( p = 0.067, η 2 = 0.010).

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