A Topical Chinese Herbal Alleviates Psoriasis by Regulating Keratinocytes Pyroptosis Through Inhibition of NLRP3 Inflammasome Activation.

Clin Cosmet Investig Dermatol · 2026 · PMC12997277 · PMID 41858598

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did not reach statistical significanceno p-value reported

Although this difference did not reach statistical significance, it aligns with MCC950’s molecular mechanism of specifically binding to the NACHT domain, suggesting its potential advantage in directly blocking inflammasome assembly.

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