Plasma lipidomic profiling reveals the potential protective role of lipids in cerebral small vessel disease.

In contrast, the mean intensity of PC was inversely associated with TNFR2 and VCAM-1, whereas Cer(d) was positively associated with fibrinogen, and PE(O) was negatively associated with TNFR2; however, these correlations were only nominally significant ( P < 0.05).

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After additional adjustment for TG, LDL-C, and HDL-C, 4 lipid species initially associated with lacunes were attenuated to marginal significance, whereas others remained significant (Table S12).

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