Among Chinese patients with LC, the HPV infection rate remains relatively high and shows an increasing trend over time, and HPV infection may increase the risk of developing LC in the Chinese population [ 42 ].
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Long-term trends of laryngeal cancer incidence and mortality in China from 2004 to 2019 by region: age-period-cohort analysis and 15-years projections to 2034.
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APC modeling in the mortality of LC across urban and rural in China Age effect After controlling for period and cohort factor, the longitudinal age curves for LC mortality in both urban and rural areas of China showed a trend of initially increasing and then decreasing slightly, with peak mortality occurring in the 80–84 age group in both urban areas and rural areas (Fig. 4 A, Supplementary Table S4).