Long-Term Antibiotic-Driven Gut Microbiota Disruption Promotes Toxigenic <i>Clostridioides difficile</i> Proliferation: A Four-Year Retrospective Study of a Single ICU Patient.

( Table 1 ) Notably, samples from polypharmacy regimens were observed to have lower indices, suggesting a potential trend towards a more pronounced impact of polypharmacy on gut microbial communities, although this difference did not reach statistical significance.

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