Patient-derived orthotopic xenograft models recapitulate the peritoneal dissemination of pancreatic cancer and delineate its transcriptional and regulatory programs.

Inhibition of TGFβ signaling with SB431542 significantly reduced organoid migratory activity, whereas blockade of STAT3 signaling showed a trend toward suppression without reaching statistical significance after multiple-comparison correction (Supplementary Fig. 5H–J and Supplementary Data 5).

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