Disulfidptosis-Induced Chondrocyte-Macrophage Crosstalk via GYS1/CCND1/NOD2 Axis Promotes Osteoarthritis Progression.

J Inflamm Res · 2026 · PMC12998651 · PMID 41859379

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Combined DTT treatment reversed the glucose starvation-induced increase in Cd86 and showed a trend toward reversing the change in Ccnd1 expression, suggesting that the decrease in Gys1 in ATDC5 cells under glucose starvation, which promotes M1 macrophage polarization, may be associated with alterations in the Ccnd1 gene.

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