Barely Significant
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Brain CB2 receptor: a new target in medication development for treating opioid use disorder in rodents.

Mol Psychiatry · 2026 · PMC12999476 · PMID 41381865

1
hedged sentence
0.2710
closest p · 5.4× alpha
0.2710
boldest claim

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showed a trendp = 0.271not close (p > 0.1)
Intranasal administration of MRI-2594 showed a trend toward reducing heroin self-administration as assessed by the number of heroin infusions (Supplementary Fig. 5A, F 2,18 = 1.404, p = 0.271) and active lever responses (Supplementary Fig. 5B, F 2,18 = 3.072, p = 0.071).

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