showed a trendp = 0.271
Intranasal administration of MRI-2594 showed a trend toward reducing heroin self-administration as assessed by the number of heroin infusions (Supplementary Fig. 5A, F 2,18 = 1.404, p = 0.271) and active lever responses (Supplementary Fig. 5B, F 2,18 = 3.072, p = 0.071).