Developmental convergence and divergence in human stem cell models of autism.

We found that they are predicted to form a highly significant protein–protein interaction (PPI) network ( Methods ; P = 0.001; Fig. 4h ) enriched for transcription factor regulation and chromatin binding related gene ontology terms (Supplementary Table 10 ).

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Although several of the genes affected by point mutations showed a trend towards downregulation ( PCDH19 , log fold change (logFC) of −0.77, false discovery rate (FDR) of 0.45; CACNA1C : logFC = −0.22, FDR = 0.78), these changes were not significant, as expected 70 – 72 (Extended Data Figs. 2 and 3 ).

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