IFNγ-associated immune-metabolic remodeling is linked to serotonin-kynurenine imbalance and cortical vulnerability in lupus-prone mice.

At the metabolic level ( Figure 6A ), plasma IFNγ concentrations showed a trend toward a positive correlation with the KYN/TRP ratio (ρ = 0.40, P = 0.06) and, more strikingly, with the QA/KA ratio (ρ = 0.77, P < 0.001), demonstrating that systemic inflammation is tightly associated with a cortical metabolic profile favoring excitotoxic outputs.

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Importantly, NfL, a sensitive biomarker of axonal injury, displayed highly significant associations with these pathways ( Figure 6C ).

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