Early life stress-induced depression reveals distinct region-specific modulation of unfolded protein response genes in the prefrontal cortex and hippocampus of rats.

Front Psychiatry · 2026 · PMC12999865 · PMID 41868836

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a decreasing trendno p-value reported

In the PFC, Xbp-1 and sXBP-1 did not show significant downregulation following maternal separation, although a decreasing trend was evident.

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showed a trendno p-value reported

Results Of the six key UPR genes ( Xbp1, sXbp1, Atf4, Atf6, Grp94 , and Chop ) studied, four genes, including Xbp-1, sXbp-1, Chop, and Grp94 , showed a trend toward downregulation in the PFC of MS group; however, none of them were significantly downregulated.

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