A validation for sex differences in gut microbiome of essential hypertension based on cohort analysis.

1 A, C), these differences did not reach statistical significance.

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Besides Roseburia intestinalis , which we observed to be significantly reduced in HTN-F, has also been demonstrated to exhibit a decreasing trend in diseases such as inflammatory bowel disease, type 2 diabetes, antiphospholipid syndrome, and atherosclerosis [ 45 , 46 ].

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It was identified in the present work that Lachnoclostridium exhibited a pronounced trend of enrichment in HTN-F, which is consistent with the findings of Moira D and colleagues, who also reported a positive correlation between Lachnoclostridium and SBP [ 35 ].

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