Laser peripheral iridotomy induced changes in eyes with primary angle closure disease.

However, for patients with PACG, there was a significant decrease in ACA by 3 months, and in ACV (borderline significance) and CACD (significant) by 6 months after LPI, though each parameter still remained above the preoperative baseline.

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Similarly, the Chennai Eye Disease Incidence Study reported a notable increase in cortical cataracts over a 6-year period, in those who had undergone LPI for PACS, 38.9% of the treated eyes as compared to 23.1% of untreated eyes ( P < 0.0001).[ 86 ] In a randomized trial by Chang et al .,[ 87 ] eyes treated with LPI exhibited a 10% higher risk of cataract progression over 6 years (95% CI 0.88 to 1.36), although this difference did not reach statistical significance.

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