Sex-Dependent Dynamics of Behavioural and Neuropathological Changes in an A53T Alpha-Synuclein Mouse Model of Parkinson's Disease.

Cell Mol Neurobiol · 2026 · PMC13003041 · PMID 41779294

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

highly significantno p-value reported

Although body weight significantly contributed to performance at both time points, the sex effect remained highly significant after adjustment, indicating that differences in body mass alone do not fully account for the observed phenotype.

also in 132,142 other papers

did not reach statistical significanceno p-value reported

Co-localisation with Dopaminergic Neurons At 60 days post-surgery, mice injected with AAV-A53T α-syn showed higher α-syn levels than controls in both the striatum (F (1,12) = 31.1, p < 0.001) and SN (F (1,12) = 7.8, p = 0.016), while this increase appeared more pronounced in males than in females, the difference did not reach statistical significance (Fig.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.