Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus.

Cell Rep · 2026 · PMC13003713 · PMID 41615800

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nominally significantno p-value reported

Moreover, nominally significant Visium sex-DE observations were resolved into significant, cell-type-specific sex-DE using Xenium; for example, MC4R showed only nominally significant sex-DE in the entire VMH but became significant at the cell-type level in CRHR2 -expressing neurons of the VMH.

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