Global analyses of genomic and epigenomic influences on gene expression reveal <i>Serpina3n</i> as a major regulator of cardiac gene expression in response to catecholamine challenge during heart failure.

As expected, we observe stronger average absolute correlation in the ISO-treated cohort ( R = 0.174 vs 0.111), and that while the control cohort’s correlations of the adrenergic signalling pathways with Serpina3n were not significantly higher than expected ( p = 0.728), the correlation of Serpina3n expression with the ISO cohort was highly significant ( p = 4.9 × 10 −5 ).

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This locus contains several interesting genes, with four genes ( Ankrd11, Spg7, Rpl13 and Fanca ) each possessing nonsynonymous mutations in one of the HMDP Recombinant Inbred founders and another, Abcb10 , showing correlation with ISO-treated heart weights ( R = 0.33, p = 1.3 × 10 −3 ) and a suggestive but not significant cis-eQTL( p = 0.018).

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