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Characterization of conserved residues in the mammarenavirus matrix protein Z using novel Lassa virus life cycle modelling assays.

Sci Rep · 2026 · PMC13005004 · PMID 41703122

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In contrast, while some of the other mutants showed a slight reduction in Z release in VLPs compared to wildtype Z, these differences were limited in magnitude and failed to reach statistical significance, suggesting that none of these other amino acids strongly impacts the budding of viral particles.

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