High mortality and amphotericin B-related nephrotoxicity in cerebral cryptococcosis in a low-resource neurology referral center: a prospective cohort study.

While a numerical trend suggested better survival with daily amphotericin compared to alternate-day dosing, the difference was not statistically significant in this cohort; conversely, statistically significant associations between treatment schedule and disability were observed, possibly reflecting complex interactions among dosing, cumulative exposure, supportive care and selection bias (sicker patients may have received alternate dosing) ( 5 , 8 , 9 ).

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41.9%; p = 0.148) but this did not reach statistical significance.

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