SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism.

Cell Rep Med · 2026 · PMC13006396 · PMID 41747718

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showed a trendno p-value reported

Hcy levels showed a trend toward elevation, consistent with impaired remethylation ( Figure 1 H).

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slightly non-significantno p-value reported

Interestingly, SRT2104-treated mice showed a slightly non-significant increase in NAMPT levels, which may reflect a partial restoration of NAD + biosynthetic capacity.

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