Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles.

Cell Rep Med · 2026 · PMC13006438 · PMID 41722565

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an increasing trendno p-value reported

did not reach statistical significanceno p-value reported

Β cell mass showed an increasing trend with LNP-induced PD-L1 expression, but did not reach statistical significance ( Figures 4 G and 4H): however, eGLP-LNP+ CD274 -treated islets displayed a decrease in severe insulitis compared to PBS, empty LNP, and unconjugated LNP+ CD274 conditions ( Figure 4 I).

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