Charting the circulating proteome in ME/CFS using cross-system profiling to uncover mechanistic insights.

Cell Rep Med · 2026 · PMC13006441 · PMID 41785863

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Although the proteomic profiles of the 21 cyclophosphamide responders versus 14 non-responders overlapped by PCA ( Supplemental Data S3 ; Document S1 : Data S1 B, Figure S2 ; Tables S4 and S5 ), several immune-related proteins (e.g., IGHE, KIT, CD80, and IL-34) showed nominally significant differences ( p < 0.05), none of which remained significant after FDR correction.

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