Prolonged intermittent theta burst stimulation enhances hippocampal plasticity via GluN2A-mediated signaling.

Although the action potential threshold was unaffected by iTBS ( Figure 8L , t = 0.5229, d f = 20, p = 0.6068), iTBS significantly increased the maximal rise slope ( Figure 8M , t = 3.398, d f = 20, p = 0.0029), spike amplitude ( Figure 8N , t = 3.054, d f = 20, p = 0.0063), peak ( Figure 8O , t = 2.962, d f = 20, p = 0.0077), with concomitant reduction in afterhyperpolarization amplitude ( Figure 8R , t = 2.209, d f = 20, p = 0.0390), while the maximal decay slope showed a trend toward significance ( Figure 8P , t = 1.820, d f = 20, p = 0.0837). 3.11 Prolonged iTBS produces long-lasting after-effects that possibly facilitate maturation and stabilization of immature synapses To evaluate whether prolonged iTBS600 produces any lasting after-effects, we performed a preliminary study on isolated synaptosomes at 7- (7 dps) and 14 (14 dps) days after last stimulation.

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GluN2A expression ( Figure 9B , Kruskal–Wallis test: H = 6.79, p = 0.0536) showed an increase at 1 dps ( p = 0.0276) that was maintained at 7 and 14 dps, however, this effect did not reach statistical significance.

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