Miniaturized IL-2/anti-IL-2 immunocytokines selectively activate and support the <i>in vivo</i> persistence of regulatory T cells.

Although this increase was still modest compared to that induced by F5111 IC or even Control IC (and did not reach statistical significance), this result was expected given the lack of an Fc domain, and this feature allows for the possibility of targeting and restricting availability of miniF5111 IC to locally expand Tregs rather than imposing systemic and persistent immune effects.

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