A modified homogeneity index for multi- target radiotherapy plans by subtracting high-dose subvolumes.

The results showed that significant differences were found only in the comparison between Formulas (1) and (2) : for BC PTV ( p = 0.024) and NPC PTV1 ( p = 0.031), while the remaining pairwise comparisons did not reach statistical significance ( p > 0.2).

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For low-dose target volumes containing high-dose target subregions, there may be significant differences in prescription doses between the two targets, and the ratio of prescription doses may vary across different disease types.

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