Comprehensive methylome and transcriptome profiling reveals specific biomarkers for bovine viral diarrhea virus persistent infection in calves.

Notably, we observed upregulation of the neutrophil extracellular trap formation pathway in Trojan dam-PI calf pairs relative to healthy dam-calf pairs, though this trend did not reach statistical significance ( p < 0.05) when comparing Trojan dams to healthy dams alone ( Figure 3D ).

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