Locomotor and endocrine alterations link to metabolic dysfunction induced by pathopharmacological interaction between neurodevelopmental disorders and antipsychotics: evidence from clinical and animal study.

Sensitivity analyses excluding the identified outliers ( Supplementary Table 4 ) showed results consistent with the primary analysis ( Supplementary Table 5 ), except that the main Group effect on LDL-c shifted from marginal significance ( p = 0.059) to statistical significance ( p = 0.047), confirming the robustness of the clinical findings. 3.1.2 Animal study 3.1.2.1 Lipid metabolism For TC levels, LMM analysis identified significant main effects of both prenatal Poly I:C exposure [ F (1, 14.1) = 15.410, p = 0.002] and sex [ F (1, 53.5) = 5.730, p = 0.020].

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After adjusting for significant covariates (Age, BMI and time of blood draw; all p < 0.01), the GLM revealed a significant main effect of Group [ F (2, 416) = 3.041, p = 0.049, partial η 2 = 0.014] and a marginally significant interaction effect between Group and Sex [ F (2, 416) = 2.812, p = 0.061, partial η 2 = 0.013; Figure 2B ].

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In females, although comparisons did not reach statistical significance, clinical groups exhibited mean reductions in ApoB levels comparable to those seen in males.

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