Pulsed Low-Dose-Rate Chemoradiation Induces Stromal Reprogramming in Pancreatic CAF-Generated ECM: Quantification by the HOST-Factor.

Gastro Hep Adv · 2026 · PMC13011201 · PMID 41884584

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0.2180

closest p · 4.4× alpha

0.2180

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did not reach statistical significanceP = .218not close (p > 0.1)

In our pooled analyses (EN = 4), Tests 1–2 (ECM anisotropy, pSMAD2/3) did not reach statistical significance when comparing Gem-PLDR to Gem-CRT ( P = .218 and P = .107, respectively), while Tests 3–5 (palladin, pFAK, α5-integrin sEVs) achieved significance ( P = .017, P = .038, P = .035).

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