Breast cancer surgery in the era of genetic uncertainty: real-world outcomes in BRCA1/2 pathogenic variants and variants of uncertain significance.

Although numerical differences in the distribution of final surgery type were observed—particularly across molecular subgroups and between BRCA1 and BRCA2 VUS carriers—these differences did not reach statistical significance. When continuous variables were evaluated, patients who underwent bilateral mastectomy were significantly younger at diagnosis compared with those who underwent non-bilateral surgery (median 43 vs. 49 years, p = 0.043).

also in 111,027 other papers