Valvular Leaflets Are Not Innocent Bystanders: Divergent Fibrotic Remodeling Accompanies Functional Mitral and Tricuspid Regurgitation.

Arterioscler Thromb Vasc Biol · 2026 · PMC13011961 · PMID 41744092

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an increasing trendno p-value reported

In FMR, antifibrotic VIC populations were significantly downregulated, whereas neutral VICs demonstrated an increasing trend, with profibrotic VICs remaining unchanged.

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did not reach statistical significanceno p-value reported

The results demonstrated that in FTR, the fibrosis score slightly improved the diagnostic accuracy of DB and TB for discriminating severity, with the combination of all 3 parameters showing the best performance, although this improvement did not reach statistical significance ( Figure S1H ).

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