Barely Significant
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Grip strength as a mediator in the relationship between physical activity and osteoporosis in older adults: Evidence from two longitudinal cohort studies.

PLoS One · 2026 · PMC13012474 · PMID 41875180

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Although physical activity had a significant protective effect against osteoporosis in the ELSA cohort, the results in the HRS cohort did not reach statistical significance, possibly due to sample differences, data processing methods, or cultural differences.

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marginally significantno p-value reported
The indirect effect (ACME) was −0.007 (95% CI: −0.009, −0.004), suggesting that grip strength still plays a marginally significant mediating role.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.