A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms.

PLoS Biol · 2026 · PMC13012477 · PMID 41875078

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did not reach statistical significanceno p-value reported

We also observed increased expression of truncated STMN2 , although this change did not reach statistical significance.

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an increasing trendno p-value reported

We observed CE splicing in cells treated with FTD seeds starting at three days post-treatment, ARHGAP32 CE splicing was significantly upregulated and HDGFL2 CE splicing showed an increasing trend.

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